Synthetic advances in macrosphelides: natural anticancer agents.
نویسنده
چکیده
Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.
منابع مشابه
Development of advanced macrosphelides: potent anticancer agents.
Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography preparation. In addition, advances in their apoptosis-inducing activities are also included.
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عنوان ژورنال:
- Molecules
دوره 19 10 شماره
صفحات -
تاریخ انتشار 2014